Algebraic equations for PK models
pk1cptiv_(t, A1 = 0, TIME, AMT, V, K, SS = 0, II = Inf) pk1cptinfusion_(t, A1 = 0, TIME, AMT, RATE, V, K, SS = 0, II = Inf) pk1cptoral_(t, A0 = 0, A1 = 0, TIME, AMT, V, K, KA, SS = 0, II = Inf) pk2cptiv_(t, A1 = 0, A2 = 0, TIME, AMT, V, K, K12, K21, SS = 0, II = Inf) pk2cptinfusion_( t, A1 = 0, A2 = 0, TIME, AMT, RATE, V, K, K12, K21, SS = 0, II = Inf ) pk2cptoral_( t, A0 = 0, A1 = 0, A2 = 0, TIME, AMT, V, K, KA, K12, K21, SS = 0, II = Inf ) pk3cptiv_( t, A1 = 0, A2 = 0, A3 = 0, TIME, AMT, V, K, K12, K21, K13, K31, SS = 0, II = Inf ) pk3cptinfusion_( t, A1 = 0, A2 = 0, A3 = 0, TIME, AMT, RATE, V, K, K12, K21, K13, K31, SS = 0, II = Inf ) pk3cptoral_( t, A0 = 0, A1 = 0, A2 = 0, A3 = 0, TIME, AMT, V, K, KA, K12, K21, K13, K31, SS = 0, II = Inf )
t | sampling times |
---|---|
A1 | initial state for A1 at TIME |
TIME | dosing time |
AMT | dosing amount |
V | volume of distribution |
K | elimination constant |
SS | 0 for no steady-state, 1 for steady-state |
II | inter-dose interval, required for steady-state calculations |
RATE | infusion rate |
A0 | initial state for A0 at TIME |
KA | absorption constant |
A2 | initial state for A2 at TIME |
K12 | transfer rate from central compartment to peripheral compartment A |
K21 | transfer rate from peripheral compartment A to central compartment |
A3 | initial state for A3 at TIME |
K13 | transfer rate from central compartment to peripheral compartment B |
K31 | transfer rate from peripheral compartment B to central compartment |
vector of same size as `t`, with the concentrations